\TSP is commonly used after cleaning with mineral spirits in order to then clean up all the mineral spirits. TSP may be used with household chlorine bleach in the same solution, and this is particularly good for removing mildew from wood. The TSP alone can cause dark stains on redwood, and bleach prevents it.

Also used in various forms as a boiler treatment chemical for calcium precipitation, as well as regulating the caustic effects of disodium phosphate in coordinated phosphate chemistry.

Also used to clean swimming pool polyester filter elements.